Clinical Trial in Nephrology at Hard End Point?
نویسندگان
چکیده
منابع مشابه
Clinical trial in nephrology at hard end point?
The clinical trial as it is conceived today has the purpose of evaluating a treatment strategy for a given disease according to a set of more or less strict rules. These rules have been narrowed in the last decade to ensure that the outcome of the trial can be interpreted with success and preferably in only one way. This interpretation should then lead to a new therapeutic strategy for the give...
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The composite of end stage renal disease (ESRD), doubling of serum creatinine and (renal) death, is a frequently used endpoint in randomized clinical trials in nephrology. Doubling of serum creatinine is a well-accepted part of this endpoint because a doubling of serum creatinine reflects a large sustained change in glomerular filtration rate (GFR) and predicts the development of ESRD. Although...
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BACKGROUND Correctly assessing and managing volume status are critical elements of daily care for patients managed by nephrologists. However, intravascular volume is difficult to assess by physical examination alone. METHODS We present vignettes illustrating the potential for using hand-carried ultrasound (HCU) to improve volume assessment in common clinical scenarios faced by the renal consu...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2004
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000113164.35698.49